Detalhe da pesquisa
1.
Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling.
Cell
; 166(1): 47-62, 2016 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27368100
2.
Synthesis of Self Permeable Antisense PMO Using C5-Guanidino-Functionalized Pyrimidines at the 5'-End Enables Sox2 Downregulation in Triple Negative Breast Cancer Cells.
Mol Pharm
; 21(3): 1256-1271, 2024 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38324380
3.
Synthesis and Biophysical Properties of Triazole-Incorporated PMOs (TzPMOs): A Convergent, Click Ligation Approach.
J Org Chem
; 89(5): 2895-2903, 2024 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38344977
4.
4'-C-Acetamidomethyl-2'-O-methoxyethyl Nucleic Acid Modifications Improve Thermal Stability, Nuclease Resistance, Potency, and hAgo2 Binding of Small Interfering RNAs.
J Org Chem
; 89(6): 3747-3768, 2024 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38394362
5.
N3-Methyluridine and 2'-O-Alkyl/2'-Fluoro-N3-methyluridine functionalized nucleic acids improve nuclease resistance while maintaining duplex geometry.
Bioorg Med Chem
; 100: 117616, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38295488
6.
Synthesis of 5'-Thiol Functionalized Morpholino Oligo-Nucleotide and Subsequent Conjugation with IGT to Improve Delivery and Antisense Efficacy In Vitro.
Bioconjug Chem
; 34(1): 174-180, 2023 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36538654
7.
Synthesis and Biophysical Studies of High-Affinity Morpholino Oligomers Containing G-Clamp Analogs.
J Org Chem
; 88(21): 15168-15175, 2023 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37843026
8.
C5-pyrimidine-functionalized morpholino oligonucleotides exhibit differential binding affinity, target specificity and lipophilicity.
Org Biomol Chem
; 21(6): 1242-1253, 2023 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36633261
9.
Guanidinium-Functionalized Flexible Azaproline Transporter for Efficient Intracellular Delivery of Proapoptotic Peptide and PDL1 Antisense Morpholino Oligo in Human Carcinoma Cells In Vitro.
Bioconjug Chem
; 33(5): 907-917, 2022 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35486710
10.
Structural Modifications to the Internal Oligoguanidinium Transporter Uncover Two Potent Analogues that Effectively Deliver the Proapoptotic Peptide in Multiple Cancer Cell Lines.
Bioconjug Chem
; 33(1): 121-133, 2022 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34915704
11.
Synthesis of Phosphorodiamidate Morpholino Oligonucleotides Using Trityl and Fmoc Chemistry in an Automated Oligo Synthesizer.
J Org Chem
; 87(15): 9466-9478, 2022 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35839125
12.
IGT mediated Nanog siRNA delivery in prostate cancer cells improves chemosensitization of Epirubicin in vitro.
Bioorg Med Chem Lett
; 76: 129017, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36209968
13.
Delivery of a Laparoscopic Bile Duct Exploration Service as a Primary Treatment Modality for Choledocholithiasis within the NHS Healthcare System.
Surg Endosc
; 36(10): 7462-7470, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35277767
14.
Cananginone Abrogates EMT in Breast Cancer Cells through Hedgehog Signaling.
Chem Biodivers
; 19(5): e202100823, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35298074
15.
Synthesis of Protected 3,4- and 2,3-Dimercaptophenylalanines as Building Blocks for Fmoc-Peptide Synthesis and Incorporation of the 3,4-Analogue in a Decapeptide Using Solid-Phase Synthesis.
J Org Chem
; 86(3): 2210-2223, 2021 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33491451
16.
Internal Oligoguanidinium Transporter: Mercury-Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization, and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitization of Taxol in MCF-7 Cells.
Bioconjug Chem
; 31(10): 2367-2382, 2020 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32986398
17.
Hedgehog Antagonist Pyrimidine-Indole Hybrid Molecule Inhibits Ciliogenesis through Microtubule Destabilisation.
Chembiochem
; 19(7): 723-735, 2018 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29363254
18.
Internal Oligoguanidinium-Based Cellular Transporter Enhances Antisense Efficacy of Morpholinos in In Vitro and Zebrafish Model.
Bioconjug Chem
; 27(10): 2254-2259, 2016 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27625020
19.
Piperazic acid derivatives inhibit Gli1 in Hedgehog signaling pathway.
Bioorg Med Chem Lett
; 26(18): 4423-4426, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27528433
20.
Cis-Trans Conformational Analysis of δ-Azaproline in Peptides.
J Org Chem
; 80(21): 10585-604, 2015 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26440300